Colecalciferol have a slow onset and a long duration of action. It is slowly released from such storage sites and from the skin where it is formed in the presence of sunlight or ultraviolet light. Vitamin D can be stored in adipose and muscle tissue for long periods of time. Vitamin D and metabolites circulate in the blood bound to a specific α-globulin. The presence of bile is essential for adequate intestinal absorption absorption may be decreased in patients with decreased fat absorption. Some of the calcium is absorbed from the intestines and the unabsorbed portion is excreted in the faeces.Vitamin D substances are well absorbed from the gastrointestinal tract. Calcium carbonate is converted to calcium chloride by gastric acid. Vitamin D is essential for promoting absorption and utilization of calcium and phosphate and for normal calcification of bone.
It plays a role in normal cardiac function, renal function, respiration, blood coagulation, and cell membrane and capillary permeability. Calcium is essential for functional integrity of the nervous, muscular, and skeletal systems.
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